No, the upper end of the guide might bend a bit just as the glass snugs up into the top position, but the rail should be tight. Looseness is bad.
Front guide rail is held to the door in this way
1. It's held to its bracket by a bolt in the middle. The head of that bolt faces toward rear of car.
2. That bracket in turn bolts to the door frame.
Make sure both bolts are tight. With the glass in the correct closed position.
As noted elsewhere use something like duct tape to cover all of the punched openings in the inner door stainless so you don't get cut when you start working on anything inside the doors.