I am not a big video game player, but I do end up playing some current PC and console games. There has been a large push for "retro" games recently and on more than one occasion the mark of the 80s "retro" game is the DeLorean. This is in no way intended to be advertising, just funny how DeLoreans are slowly getting bigger in the media.
First off, the easy one, the Back to the Future game. A point-and-click style RPG where you are Marty McFly and go on crazy adventures with Doc. The story is meant to be an alternate to the original BttF movies, splitting off fairly early on. http://www.telltalegames.com/bttf Should be obvious how the DeLorean is involved.
Hotline Miami is meant to be a GTA style game. I personally did not like it, spent maybe 5 minutes playing. However, your main mode of travel is a top-down view of a DeLorean: http://hotline-miami.wikia.com/wiki/Car Although, the headlights are wrong, but its very much a D.
Game Dev Tycoon is a Tycoon style game set in the 80s and moving forward of running a game development studio. I have never actually played this game, but the images of it look like you start out working in your garage. In said garage is a mostly covered up car that is unmistakably a DeLorean; it even has oil spots, albeit on the wrong side of the car: http://www.greenheartgames.com/app/game-dev-tycoon/ (scroll down a bit to get the picture I am talking about).